PrecisionBiotic cultures are unique bacterial cultures that have been specifically researched and rigorously tested by PrecisionBiotics.
All our products contain bacteria that occur naturally in the human gut and are at home there.
We spend many years observing and testing them in real people to ensure they have the precise qualities needed and that they meet our rigorous safety standards.
We have created special formulations which are stable, ensuring that none of our products need refrigeration.
Most yoghurts contain bacterial cultures. If bacterial cultures have been added during the manufacturing process, they may not be cultures that have been tested in clinical trials or that are native to the human gut.
We're often asked why our products contain only 1 or 2 types of bacteria, instead of a mix of 5 or even 10 types.
As scientists, we know that mixing multiple bacterial cultures can mean their individual qualities are affected. Different cultures behave in different ways and may even have competing effects. And cultures of animal origin are not native to the human gut so we do not add them.
It is the specific strain of bacteria and how that culture interacts with your unique gut bacteria that determines whether you will notice a difference.
So, our focus is on investing to find the best bacterial culture for each specific gut action. We then put each through a rigorous series of tests, culminating in clinical trials in the UK and Europe.
We produce a pure formulation, with no added bulk yoghurt or animal cultures, to provide a PrecisionBiotic® product that we can guarantee and that clinicians can recommend.
We also guarantee that the number of bacteria is the optimal amount for each PrecisionBiotic and the human gut.
The 1714-Serenitas™ culture in Zenflore is a unique bacterial culture that has been clinically studied in people with everyday stress1. It's been shown to reduce the level of our stress hormone, cortisol and the impact of stress on daily life1.
Zenflore is the only product that contains the 1714-Serenitas culture.
This unique culture in Zenflore is a bacterial culture that occurs naturally in the human gut. It is part the Bifidobacteria family, one of the first kinds of bacteria passed by mother to baby at birth2.
It is a PrecisionBiotic which work specifically on the area for which it was developed.
Yes. Zenflore contains the 1714-Serenitas culture, a bacterial culture that occurs naturally in the human gut.
It's part of the Bifidobacteria family of bacteria that are given by mothers to their babies at birth2.
To ensure this natural culture reaches your gut with its properties intact, we have created a special formulation which is stable at room temperature so it does not need refrigeration.
Zenflore contains the natural bacterial culture 1714-Serenitas plus specially selected B vitamins:
- Thiamine (vitamin B1)
- Riboflavin (vitamin B2)
- Niacin (vitamin B3)
- Vitamin B6
- Folic acid
- Vitamin B12
- Pantothenic acid
There are also some excipients to help with formulation, all held in a clear capsule.
There are no known allergens in Zenflore. All raw materials used for Zenflore do not contain any allergen listed in the Directive 2007/68/EC and its amendments. The facilities we use to manufacture also ensure that during the production process, raw materials are not exposed to cross contamination from allergens.
Please see the outer pack for a full ingredient list.
A single Zenflore capsule contains around 1 billion bacteria, or 1x109 colony forming units (CFUs), at the time of manufacture.
The quantity of bacteria in each capsule has been chosen for optimal action. It has been rigorously tested by scientific teams, culminating in testing in clinical trials.
Zenflore contains a single culture, the specially selected Bifidobacterium longum 1714-Serenitas culture. As scientists, we know that mixing multiple bacterial cultures does not guarantee that each will retain its properties or that different cultures will even complement each other. Different cultures behave in different ways and may even have competing effects. Cultures of animal origin are not native to the human gut so we do not add them.
Stress is often described as a feeling of being overwhelmed, worried or run-down.
In everyday terms, stress is a feeling that people have when they are overloaded and struggling to cope with demands. Stress can affect people of all ages, genders and circumstances.
Some stress can be beneficial at times, producing a boost that provides the motivation, drive and energy to help people get through situations like exams or work deadlines3. However, an extreme and prolonged amount of stress can have health consequences and adversely affect the immune, cardiovascular, neuroendocrine and central nervous systems4.
Modern life can be busy and often mean feeling stressed. Stress left unmanaged can influence health and well-being affecting mind and body.
Signs of stress include5:
Loss of sleep
Weakened immune system
The connection between our brain and our gut is already part of how we describe experiences - having a "gut-wrenching" moment or feeling nervous with "butterflies" in the stomach. These expressions have become commonplace for a reason. We now know there is a connection between our brain and our gut.
Scientists call this connection the gut-brain axis - the two-way dialogue between the brain and the gut where information flows between the 2 organs6.
There are three main communication channels between the brain and the gut8:
- the nervous system
- the immune system
- the endocrine system (hormones)
A key physical link that relays the information between the gut and the brain is the vagus nerve9. 80-90% of nerve fibres in the vagus nerve are going from the gut to the brain7.This nerve relays information using molecules called neurotransmitters (chemical messengers).
Evidence shows that bacteria (also known as microbes) in the gut can act on the gut-brain axis and hence influence gut-brain communications13.
The bacteria in your gut produce more than 90% of the serotonin found in your body 10 - this a neurotransmitter that can affect your mood and feelings of happiness and pleasure and research has shown that gut bacteria can impact its production in the gut8.
Current research indicates that a gut with a healthy microbiota is a strong predictor of emotional and mental wellbeing6.
Zenflore, with the unique 1714-SerentitasTM culture and specially selected B vitamins, provides complete support for your mind and body during busy and demanding times, helping to support a healthy mind and combat stress-related fatigue11,12.
The special 1714-Serenitas culture in Zenflore was discovered and developed by PrecisionBiotics®, in partnership with scientists and clinicians from one of the world’s leading centres of research on the microbiome and the gut-brain axis.
It has been clinically studied in people with everyday stress and shown to reduce the level of our stress hormone1.
By combining this unique Bifidobacterium longum 1714TM culture with specially selected vitamins, Zenflore provides a complete solution to help support a healthy mind and combat stress-related fatigue 11,12.
This naturally occurring bacteria is part of the family of bacteria given by mother to baby at birth2.
Zenflore is suitable for those dealing with the challenges of everyday stress. Zenflore is not a medicine and is not a substitute for any medication prescribed for you by your doctor. Do not discontinue any medication without consulting your doctor.
The 1714-Serenitas culture in Zenflore has been shown in clinical trials to activate your stress coping centres and to reduce levels of your stress hormone, cortisol1.
It acts by becoming part of the gut microbiota that are involved in the gut-brain axis, the 2-way communication between brain and gut via the vagus nerve8.
The culture in Zenflore is also involved in regulating your immune system, which plays an important role in health and well-being.
Each live culture has its own properties and all cultures are different. Each culture may impact the gut but this does not mean it will also have an impact on the brain.
Very few cultures have been studied for their impact on the brain, and those that have been studied showed varying results.
The 1714-Serenitas culture has been studied in clinical trials by scientists and clinicians1. This culture has been shown to activate your stress coping centres, and to reduce levels of your stress hormone, cortisol1.
Take one capsule every day. Zenflore can be taken with or without food, at any time of the day.
Note: Fruit juices are generally acidic and acid can damage the 1714-Serenitas culture. We recommend taking Zenflore with water or milk or less acidic drinks e.g. soya, almond or rice milks.
However, Zenflore can be taken as part of a meal that has fruit juice, as the food will help protect the culture in Zenflore.
If there is an issue with swallowing the capsule, the capsule can be opened and sprinkled over food or mixed with fluids.
Do not exceed the stated dosage. Food supplements should not be used as substitutes for a varied diet and a healthy lifestyle. Keep out of the reach of children.
Zenflore acts immediately and begins to prime your gut where it is needed. During the first 2 weeks it will help reset your system. It is important to take Zenflore every day. To see the full effects of Zenflore can take approximately 4 weeks, depending on the individual gut.
As Zenflore begins to gently prime the gut, some people may experience mild and temporary changes in their gut during these first weeks.
In rare cases it may take Zenflore longer than 4 weeks to prime an individual gut, possibly up to 8 weeks. If you have any questions about Zenflore, please contact our Careline on
Ireland: +353 21 2066012
UK: +44 330 057 8598
Zenflore stays in your gut for as long as you continue to take it.
It performs it's action in the gut and then will naturally be swept out by regular bowel movements.
As long as you feel the stress triggers are there, taking Zenflore will provide support for your mind and body during busy and demanding times11,12.
By taking a single capsule of Zenflore every day you can ensure your gut remains primed. If you miss a dose, take it as soon as you remember.
Our PrecisionBiotics scientists have developed a convenient, once daily formulation, specially designed to reach the human gut with its properties intact.
PrecisionBiotics formulations are stable, ensuring that none of our products need refrigeration.
No refrigeration required. Store below 25°C.
For best results we recommend you store Zenflore securely closed in the original packaging.
No. The 1714-Serenitas culture in Zenflore has been shown in clinical studies to increase the level of activity in certain brain centres that are correlated with a feeling of greater vitality1.
Daily stress is often associated with sleep problems. As stress is managed, disrupted sleep can be reduced.
Zenflore, with the natural 1714-Serenitas culture and specially selected vitamins, has been formulated to provide a complete solution to help combat and reduce tiredness and fatigue12.
Yes. The 1714-Serenitas culture in Zenflore has been shown in clinical trials to reach the digestive system with its properties intact.
The 1714-Serenitas culture in Zenflore, can be inactivated by alcohol.
We recommend not drinking alcohol for a few hours after taking Zenflore.
Each gut is individual and not all stress responses are the same. For some people, it may take longer for Zenflore to prime the gut.
If signs of stress persist please refer to your GP for further advice.
Zenflore is available now from all good pharmacies.
If Zenflore is not available on the shelf, it can still be ordered from the pharmacy or healthfood shop. Just ask the pharmacist to order Zenflore for you, for pickup in store.
At €32.95 for a months supply, Zenflore costs just over €1 per day to provide complete support for your mind and body during busy and demanding times11,12.
One capsule provides the recommended dose of the unique 1714-Serenitas culture plus 8 types of B vitamin.
By taking Zenflore you may also be able to avoid the costs of other products you may have had to purchase before.
Look out for our special offers on our website and from our pharmacy and healthfood store partners.
This is a natural food supplement and there are no known side effects with Zenflore.
The 1714-Serenitas culture in Zenflore has been studied by doctors and scientists in well controlled clinical trials.
As Zenflore begins to gently prime the gut, some people may experience mild and temporary changes in their gut.
This culture is part the Bifidobacteria family of bacteria, one of the family of bacteria passed by mother to baby at birth, that lives naturally in the human gut.
If you have any questions about Zenflore, please call our Careline on: 021 2066012 (UK only: +44 330 057 8598)
Yes, Zenflore can be taken with other supplements and medicines.
There are no known interactions with other supplements and medicines. If you have questions before taking the Zenflore food supplement, please consult a doctor or healthcare professional.
Zenflore is not a substitute for any medication prescribed for you by your doctor.
Do not discontinue any medication without consulting your doctor.
As happens with most bacterial cultures, a dose of antibiotics could inactivate the bacterial culture in Zenflore.
If you have to take a course of antibiotics, we advise that you take the dose of the antibiotic at a different time to your daily dose of Zenflore.
Yes, Zenflore can be taken at the same time as Alflorex®.
The cultures in both products are naturally occurring ‘friendly’ bacteria and are part of the same family of bacteria given by mother to baby at birth.
No. Zenflore is not a substitute for any medication prescribed for you by your doctor.
Do not discontinue any medication without consulting your doctor.
This is a natural food supplement. The 1714-Serenitas culture in Zenflore is part the family of bacteria passed by mother to baby at birth, that lives naturally in the human gut.
The recommended dosage of Zenflore is one capsule per day. This is the dosage that PrecisionBiotics recommends, and that has been tested and validated in clinical trials.
There are no known allergens in Zenflore. None of the raw materials used for Zenflore contain any allergen listed in the Directive 2007/68/EC and its amendments.
The facilities we use to manufacture also ensure that during the production process, raw materials are not exposed to allergens cross contamination.
Zenflore is free from gluten, soya, dairy, lactose and sugar.
Zenflore is suitable for children aged over 3 years. This is a natural bacterial culture, part of the family of bacteria given by mother to baby at birth.
Bifidobacteria decline with age so consumption of this supplement will help to maintain healthy levels of this bacteria.
For further advice, please talk to your health care professional.
Each capsule contains only a residual amount of sugar and will not impact on blood glucose levels.
Our Careline team have worked with thousands of our customers to answer any type of question about our products.
If you have a question, please call our careline, email us or visit our website:
1) Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognitive in healthy volunteers. Allen et al., Transl Psychiatry, 2016
2) Diversity of Bifidobacteria within the Infant Gut Microbiota. Turroni et al. 2012.
4) Anderson, N.B. (1998). "Levels of Analysis in Health Science: A Framework for Integrating Sociobehavioral and Biomedical Research," Annals of the New York Academy of Sciences, Vol. 840, pp. 563-576.
6) Psychobiotics and the gut–brain axis: in the pursuit of happiness. Zhou et al., Neuropsychiatric Disease and Treatment 2015
7) Tubbs RS, Rizk E, Shoja MM, Loukas M, Barbaro N, Spinner RJ. Nerves & Nerve Injuries: Vol 1: History, Embryology, Anatomy, Imaging, and Diagnostics. Cambridge, Massachusetts: Academic Press (2015).
8) The impact of gut microbiota on brain and behaviour: implications for psychiatry Dinan et al., Clinical Nutrition & Metabolic Care 2015
9) Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders. Breit et al., Front Psychiatry. 2018
10) The Gut Microbiome and the Brain. Leo Galland, J Med Food, 2014
11) Biotin, Folate, Niacin, Thiamine, B6, B12: Contributes to normal psychological function.
12) Folate, Niacin, Pantothenic Acid, Riboflavin, B6 and B12: Contributes to reduction of tiredness and fatigue.
13) Neuropharmacology 2017 Jan;112(Pt B):399-412. Kennedy PJ, Cryan JF, Dinan TG, Clarke G.
We're a company that's dedicated to bringing the best of nature's friendly bacteria to help consumers and clinicians all over the world.
We're proud of our record of discovery and our partnership with one of the world's leading